Protease Inhibitors and Phosphatase Inhibitors
Medchemexpress LLC Calcineurin autoinhibitory peptide | 148067-21-4 | 100.0% | 2930.32 | 10 MG
Calcineurin autoinhibitory peptide is a selective inhibitor of Ca2+/calmodulin-dependent protein phosphatase (calcineurin). It could protect neurons from excitatory neuronal death.
- Selective inhibitor of calcineurin
- IC50 of approximately 10 μM
- Protects neurons from excitatory neuronal death
Electron Microscopy Sciences Substrate of Silver Coated 2" Silicon Wafer, P-Type <100>, 50 mm
EMS offers a variety of economically priced coated substrates. All coatings are deposited under vacuum using electron beam evaporation. These high quality substrates are coated with 500 Angstroms (50 nm) of silver, with a thin titanium adhesion layer (2-7 nm) between the glass and silver coating. All substrates are pre-cleaned using an ion source for quality assurance. Autoclavable. P-Type <100> wafer.
Dimensions: 50 mm
Material: Silicon Wafer P/Boron
Abcam Puromycin dihydrochloride, Protein biosynthesis inhibitor, 250MG
MW 544.4 Da, Purity >98%. Aminonuclease antibiotic agent. Protein biosynthesis inhibitor. Induces cell cycle arrest in G2/M phase and apoptosis. Inhibits transport of proteins into mitochondria. Inhibits translation in vivo.
The product is subject to the following: Abcam Restricted Use Statement
Medchemexpress LLC Kras G12d inhibitor 1 | 2621928-43-4 | 98.5% | C33H32F2N6O2 | 10MG
KRAS G12D inhibitor 1 is a small-molecule research compound that selectively targets the KRAS G12D mutant. It is supplied as a solid or as a DMSO stock solution for in vitro biochemical and cellular studies and has been shown to inhibit KRAS G12D-mediated ERK phosphorylation with high potency.
- Potent inhibition of KRAS G12D-mediated ERK phosphorylation (IC50 approximately 0.8 nM).
- Suitable for biochemical and cellular assays investigating KRAS G12D-driven signaling.
- Available as a solid and as a DMSO stock solution for flexible dosing.
- Recommended storage conditions provided to preserve compound stability.
- Reported high purity (approximately 98.5%) according to supplier documentation.
Cayman Chemical STOML3 InhIbItr OB-1 25mg
An inhibitor of STOML3 oligomerization; inhibits oligomerization of mouse and human STOML3 in cell-free assays at 10 µM; reduces Piezo1 channel current amplitude in Neuro2a cells; inhibits tactile perception in wild-type mice and reduces tactile allodynia in a mouse model of streptozotocin-induced diabetic neuropathy
Sigma Aldrich Fine Chemicals Biosciences Cytisine phyproof(R) Reference Substance | 485-35-8 | MFCD00136048 | 10MG
Cytisine phyproof(R) Reference Substance | Purity: >=98.0% (HPLC) | Mol Wt: 190.24 | 485-35-8 | MFCD00136048 | 10MG
AG Scientific Inc PMSF 25 G
Phenylmethylsulfonyl fluoride (PMSF) is an important serine protease inhibitor commonly utilized by biochemists and researchers. PMSF is often used to prepare cell lysates, helping to preserve critical samples.Acting as a non-specific inhibitor, PMSF is often used to protect samples against the digestive functions of proteases, such as trypsin, chymotrypsin, and thrombin, as well as other enzymes. It is also used for protein purification when preparing protein extracts taken from cells and tissues.By deactivating the serine hydroxyl group of any enzyme that contains this amino acid, PMSF prevents the degradation of proteins of interest. Based on its short half-life, PMSF must be added during each purification step.
Medchemexpress LLC BRM/BRG1 ATP inhibitor-2 | 2368900-77-8 | MFCD34676590 | 99.7% | 412.53 g·mol⁻¹ | C20H20N4O2S2 | 5 MG
BRM/BRG1 ATP Inhibitor-2 is a small-molecule inhibitor of the ATPase activity of BRG1 and BRM, core ATPase subunits of the SWI/SNF (BAF) chromatin remodeling complex. It is provided for research use to support biochemical and cell-based investigations into BAF-related disorders and chromatin remodeling mechanisms.
- Potent inhibition of BRG1 and BRM ATPase activity.
- High chemical purity suitable for biochemical assays.
- Soluble in common organic solvents for stock preparation.
- Suitable for in vitro and preclinical cell-based studies.
- Provides a tool to study chromatin remodeling and disease mechanisms.
Abcam FAK Inhibitor 14, FAK autophosphorylation inhibitor, 10MG
MW 174.63 Da. Selective focal adhesion kinase (FAK) autophosphorylation inhibitor (IC₅₀ = 1 μM). No significant activity at other kinases including EGFR, PDGFR and IGF-RI. Increases cell detachment and inhibits cell adhesion in cancer cells. Anticancer agent. Active in vivo and in vitro.
The product is subject to the following: Abcam Restricted Use Statement
Abcam PD 168393, EGFR inhibitor, 1MG
MW 369.2 Da, Purity >98%. Potent, irreversible, cell-permeable, selective EGFR inhibitor (IC₅₀ values are 0.7, 0.08, 5.7, 12 and 15 nM for EGF receptor tyrosine kinase, erbB1, erbB2, erbB4 and SK-BR-3, respectively). Binds to the catalytic domain. Inhibits cancer cell growth. Blocks reactive astrogliosis and shows neuroprotective effects in vivo. .
The product is subject to the following: Abcam Restricted Use Statement
Cayman Chemical CBF InhIbItr 10mg
A small molecule that binds to CBFβ and inhibits its association with Runx1 (IC50 = 3.2 µM); blocks CBFβ-Runx1 interactions in ME-1 cells, acute myeloid leukemia cells harboring dysfunctional CBF, reducing proliferation without toxicity
Cayman Chemical Mpro InhIbItr 11b 10mg
An inhibitor of Mpro (IC50 = 0.04 µM in a TR-FRET assay); reduces viral yield in the culture supernatant of SARS-CoV-2-infected Vero E6 cells (EC50 = 0.72 µM); reduces viral RNA copy numbers in the same model from 1.85-50 µM
Apexbio Technology LLC Protease Inhibitor Cocktail (EDTA-Free, 200X in DMSO), 1ml x 50
Equivalent to Sigma P1860, for use in tissue culture media to prevent proteolytic degradation of secreted proteins. Other sizes are available. Please inqury us for quote.
Apexbio Technology LLC Protease Inhibitor Cocktail (EDTA-Free, 100X in DMSO), 1mlx10
Equivalent to Sigma P9599, for use with plant cell and tissue extracts to increase protein stability. Other sizes are available. Please inqury us for quote.
Cayman Chemical ERK InhIbItr 1mg
A cell-permeable inhibitor that binds ERK2 near its docking domain (KD = 5 µM); blocks ERK-specific phosphorylation of Rsk-1 and TCF/Elk-1 but does not affect ERK1/2 phosphorylation by MEK1/2; completely prevents proliferation of several cancer cell lines